Sickle Cell Disease action items
To be revisited in the fall 2023
statistical analyses
- If we are just studying SCD, can use statstical methods to look for covariants
Ontology/KG methodology
- create ontological representation of SCD concepts (could we extend SCDO or reuse terms in SCDO)?
- They do not cover the cellular and biochemical markers- this is a gap that we could fill
- We could model lab measurements in CPONT
- map SCD patient data to ontology terms
- incorporate patient-level data and ontology mappings into KG
Potential analyses
- cluster patients based on their data
- define disease severity/stratify patients based on disease severity
- Frequency of vaso-occlusive crisis
- Pain
- Ranges of biomarkers
- could do semantic similarity profile analysis of patients
questions to be answered
- is there a relationship b/w biomarkers and clinical manifestations
- Could we look at other patients who have specific biomarkers and see what drugs they respond to
cc @rwalls